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cell signaling technology 93334  (Cell Signaling Technology Inc)
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Cell Signaling Technology 93334, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a , TDP-43 KD lengthened the 3′ UTR of <t>TMEM106B</t> . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .
Antibody Against Tmem106b, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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antibody against tmem106b - by Bioz Stars, 2026-09
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antibodies against tmem106b  (Cell Signaling Technology Inc)
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a , TDP-43 KD lengthened the 3′ UTR of <t>TMEM106B</t> . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .
Antibodies Against Tmem106b, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rabbit+anti+tmem106b/TMEM106B+Rabbit+mAb/pm41120751-187-33-37
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antibodies against tmem106b - by Bioz Stars, 2026-09
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a , TDP-43 KD lengthened the 3′ UTR of <t>TMEM106B</t> . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .
Tmem106b, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rabbit+anti+tmem106b/TMEM106B+Rabbit+mAb/pmc12586192__41593_2025_2049_MOESM2_ESM-42-144-145
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anti tmem106b antibody  (Cell Signaling Technology Inc)
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a , TDP-43 KD lengthened the 3′ UTR of <t>TMEM106B</t> . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .
Anti Tmem106b Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rabbit+anti+tmem106b/TMEM106B+Rabbit+mAb/pmc11377756__42003_2024_6810_MOESM1_ESM-5-0-2
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anti tmem106b antibody - by Bioz Stars, 2026-09
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homemade rabbit anti tmem106b icd  (Proteintech)
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a , TDP-43 KD lengthened the 3′ UTR of <t>TMEM106B</t> . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .
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rabbit anti- tmem106b antibody  (Proteintech)
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a , TDP-43 KD lengthened the 3′ UTR of <t>TMEM106B</t> . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .
Rabbit Anti Tmem106b Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti tmem106b  (Cell Signaling Technology Inc)
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a , TDP-43 KD lengthened the 3′ UTR of <t>TMEM106B</t> . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .
Rabbit Anti Tmem106b, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rabbit+anti+tmem106b/TMEM106B+Rabbit+mAb/pm40269985-132-8-12
Average 95 stars, based on 1 article reviews
rabbit anti tmem106b - by Bioz Stars, 2026-09
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Image Search Results


a , TDP-43 KD lengthened the 3′ UTR of TMEM106B . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .

Journal: Nature Neuroscience

Article Title: TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes

doi: 10.1038/s41593-025-02049-3

Figure Lengend Snippet: a , TDP-43 KD lengthened the 3′ UTR of TMEM106B . b , Targeted APA analysis of TMEM106B using RNA-seq from FTD/ALS brain samples, shown in box plots with centerline, median; box limits, upper and lower quartiles; and whiskers, minimum and maximum. c , Level of the long TMEM106B 3′ UTR is substantially increased in the frontal cortices of FTLD–TDP patients ( n = 221) compared with controls ( n = 53). Data are presented as mean ± s.e.m.; P values were calculated using two-tailed Mann–Whitney test. d , Western blot shows reduced TMEM106B dimer levels after 12-day TDP-43 KD. Quantitation of protein levels ( n = 3 per condition) is presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. e , The schematic of the luciferase activity assay for TMEM106B 3′ UTRs. f , The presence of the long TMEM106B 3′ UTR reduces translation efficiency. Dot plots show that the longer TMEM106B 3′ UTR led to lower luciferase activity (left) and higher RNA levels (right). No insert, a dual-luciferase reporter without TMEM106B 3′ UTRs; short, a dual-luciferase reporter with the short TMEM106B 3′ UTR; long, a dual-luciferase reporter with the long TMEM106B 3′ UTR. Data are presented as mean ± s.e.m.; P values were calculated using one-sided Student’s t -test. Panel e created with BioRender.com .

Article Snippet: Membranes were blocked in 5% nonfat dry milk in Tris-buffered saline with Tween 20 for 1 h and then incubated overnight at 4 °C in blocking buffer containing the antibody against TMEM106B (1:500; Cell Signaling Technology, 93334).

Techniques: RNA Sequencing, Two Tailed Test, MANN-WHITNEY, Western Blot, Quantitation Assay, Luciferase, Activity Assay